(Watch).Boston.Red.Sox.vs.St.Louis.Cardinals.Live.Stream.Online.Game.1.MLB.World.Series.2013 The St. Louis Cardinals take aim at their second World Series title in three years, as they kick off the 109th edition of the Fall Classic against the Boston Red Sox on Wednesday at Fenway Park.

These teams haven't met in interleague play since 2008, but are certainly no stranger to one another in the World Series, as this will be the fourth time these teams have faced off and the first since 2004 when the Red Sox, of course, ended their 86-year drought with a four-game sweep.

St. Louis beat Boston in the World Series in 1946 and '67.

You can't ask for a more balanced matchup, as both teams topped their respective leagues with a 97-65 mark. Actually, there home/road splits were almost identical, as well, with the Red Sox going 53-28 at home and 44-37 on the road, while the Cardinals were 54-27 and 43-38, respectively.

It's the first time since 1999 (Yankees and Braves) that the best teams in each league will be facing off in this round.

St. Louis is back in the Fall Classic for the third time since 2004 after beating Pittsburgh in five games of the NLDS, then taking out the Los Angeles Dodgers in six games of the NLCS.

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